Is HOXA2 a transcription factor?
Is HOXA2 a transcription factor? If you look at a human face, you’ll notice that the two sides of the face are symmetrical. This symmetry makes the face look symmetrical. For example, when you see someone with a full face of teeth on both sides, you would think that they are perfectly symmetrical. This is the effect of HOXA 2. This gene is located on chromosome 7 (at position 7p14) and encodes a protein called Homeobox Transcription Factor 2 (HOXA-HOXB). It plays a very important role in the formation of our faces and ear.
A defect in this gene results Hoxa3 in a condition known as Microtia, which is an abnormality that causes the external ear to be small and/or missing. Hearing defects, which are caused by microtia, are known as Pendred’s Syndrome or Mondini’s Syndrome. They affect one of the middle ear ossicles, causing conductive deafness or hearing loss.
In addition to the external ear, the ear canal contains hair cells. These cells provide mechano-electrical transduction between sound signals and the brain. They help us hear sounds and they also detect touch. The ear drum is composed of the tympanic membrane, middle ear and outer ear canal.
Hoxa 2 controls the embryonic development of the lower and middle part of the face and of the middle ear. Mutations in it are known to cause microtia, hearing impairment, and cleft palate.
This gene is located at 7p14 and regulates the development of the lower part of the face and of the ear. It is highly conserved across species.
When Hoxa 2 is defective, we see microtia, hearing impairment, and cleft palate. Microtia is the congenital absence of the pinna of the ears. Cleft palate is an abnormal cleft of the upper lip in the mouth. Cleft palate is the second most common facial deformity (after facial clefts).
When we are young, we make a lot of mistakes. Some of those mistakes can be very serious and have severe consequences. The most common mistake made by us when we are young is talking too much. For example, we talk too much with our friends, and we say too many things about ourselves. We forget that we have to be careful when we are talking because if we say something that we shouldn’t have said, we can lose a lot. We may have to apologize and explain to the person what we did wrong.
But the best thing we can do is learn from our mistakes and never repeat them. We should pay more attention to the things that happen to us. If we keep doing this, we can avoid making similar mistakes. When we talk about the development of the lower and middle parts of the face, we are talking about the front of the head. This is an area that is protected by our facial muscles.
The part that contains the muscles is called the temporal region. It begins between the ear and the hairline, and it ends between the eyebrows and the eyes. This is a very important area because it contains the structures that are responsible for your ability to hear and to speak. When we talk about the middle ear, we are talking about the area behind the ear.
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